3’UTR variation in cancer genes has a potential to affect cancer susceptibility and disease outcome. This project seeks to study single nucleotide polymorphisms (SNPs) in miRNA binding sites in the 3’UTR of genes linked to non-small cell lung cancer (NSCLC) development with the aim of identifying novel genetic variants involved in the molecular mechanisms of cancer. The project will use online bioinformatic tools to identify 3’UTR SNPs in miRNA target sites, followed by functional analysis to assess the effects of relevant SNPs on regulating their target genes and cancer phenotypes. Modern genome editing and miRNA target site blocker technologies as well as Next generation sequencing and PCR based methods will be used to validate the association between the SNPs and cancer development and progression.
Training and Development
The successful candidate will receive comprehensive research training including technical, personal and professional skills.
All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities.
Entry criteria for applicants to PHD
· A minimum of a 2:1 first degree in a relevant discipline/subject area with a minimum 60% mark in the project element or equivalent with a minimum 60% overall module average.
PLUS
· The potential to engage in innovative research and to complete the PhD within a 3.5 years
· A minimum of English language proficiency (IELTS overall minimum score of 7.0 with a minimum of 6.5 in each component)
· A background or strong interest in cancer biology
· A MSc in a relevant discipline is desirable.
For further details see: https://www.coventry.ac.uk/research/research-students/making-an-application/
How to apply
To find out more about the project please contact Dr Anne Reiman [Email Address Removed]
To apply on line please visit: https://pgrplus.coventry.ac.uk/
All applications require full supporting documentation, a covering letter, plus a up to 2000-word supporting statement showing how the applicant’s expertise and interests are relevant to the project.
Interview dates: Will be confirmed to shortlisted candidates
Start date: Sept 2021
Duration of study: Full-Time – between three and three and a half years fixed term
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