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Genetic dissection of a complex immune locus in barley (MOSCOUS20DTP)

  • Full or part time
  • Application Deadline
    Monday, November 25, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Stripe rust (Puccinia striiformis) is an obligate biotrophic fungal pathogen of grasses. There are several adapted forms that preferentially infect different species including wheat and barley. We previously established that three genetic loci (Rps6, Rps7, Rps8) contribute to maintaining host species specificity of wheat stripe rust in barley. Rps6 and Rps7 prevent the colonization of wheat stripe rust, whereas Rps8 prevents the completion of the full lifecycle of wheat stripe rust. Fine-mapping of Rps8 identified a 1 Mb physical interval encompassing several candidate genes. This PhD project involves the use of forward genetics (mutagenesis) and reverse genetics CRISPR/Cas9-mediated gene editing) to identify genes that are required for Rps8-mediated resistance.

This PhD project will be supervised by Dr. Matthew Moscou at The Sainsbury Laboratory. The Moscou group focuses on understanding the molecular basis of non-host Resistance, with the long-term goal of translating these discoveries into wheat to engineer resistance. This PhD will therefore provide an excellent training in molecular plant pathology, genetics, genomics, next-generation sequencing, and bioinformatics in a world-renowned environment for academic and research excellence.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 7th, 8th or 9th January 2020.

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website: https://biodtp.norwichresearchpark.ac.uk/

Funding Notes

For funding eligibility guidance, please visit our website: View Website. Full Studentships cover a stipend (2019/0 rate: £15,009pa), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.

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