About the Project
Dr Donald Lyall
Dr Simon Cox
Apolipoprotein e (APOE) e4 genotype, found in around 25% of the population, has been known as a genetic risk factor for Alzheimer’s disease (AD) since 1993, but we still do not understand the underlying mechanisms in terms of brain structure and function, nor the conditions (lifestyle; environmental; genetic) in which its effect is most pronounced. Most studies conducted to date are small, do not consider potential confounds (e.g. smoking or deprivation), and employed widely varying methods in brain structure/function analyses. To demonstrate interactions between APOE and other risk factors reliably in high-quality existing datasets would have significant potential implications for worldwide public health and clinical practice. This project will make use of UK Biobank and Lothian Birth Cohort 1936, two cohorts with dovetailing and complimentary characteristics, to understand what factors modify the effects of APOE on brain health (cognitive abilities; longitudinal decline across time; clinical dementia), and via what aspects of brain structure and function (assessed by brain magnetic resonance imaging).
This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.
All applications should be made via the University of Edinburgh, irrespective of project location via the link below.
Please note, you must apply to one of the projects and you must contact the primary supervisor prior to making your application. Additional information on the application process is available from the link above.
For more information about Precision Medicine and what is required when submitting an application, please visit:
Start: September 2021
Qualifications criteria: Applicants applying for an MRC DTP in Precision Medicine studentship must have obtained, or will soon obtain, a first or upper-second class UK honours degree or equivalent non-UK qualification, in an appropriate science/technology area. The MRC DTP in Precision Medicine grant provides tuition fees and stipend of at least £15,285 (UKRI rate 2020/21).
Full eligibility details are available: http://www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/
Enquiries regarding programme: [Email Address Removed]
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