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Genetics of Progression, Complications and Severity (PROCeS) - Reference: T3/18


Department of Health Sciences

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Prof F Dudbridge , Dr C Neilson No more applications being accepted Competition Funded PhD Project (Students Worldwide)

About the Project

In most diseases, genetic analyses generate a list of susceptibility genes. Yet clinicians treat people who are affected, beyond susceptibility. Thus, it would be better if we could test whether genetic variation impacts disease progression, complications and severity (PROCeS), the very three overlapping features which clinicians want to control with therapeutics. In practice the analysis of PROCeS faces difficulties including variable definitions of relevant measurements, and biases in statistical analysis due to how subjects are selected for study. In this project we will evaluate alternative measurements that are commonly available in research studies, which may act as suitable proxy measurements of PROCeS. These will be compared to “gold standard” measurements available in a limited number of studies. The measurements we will consider include age-of-onset as a proxy for progression, comorbidities for complications and medication usage and hospitalizations for severity. We expect that our approaches will identify genes that are also found through more traditional approaches for the genetics of PROCeS. The adjustment for selection bias will give us more accurate estimates of disease prognosis and allow us to prioritize drug target candidates that should be more effective than disease susceptibility targets.

Entry requirements
• Candidates applying to the 4-year PhD should hold or expect to hold a UK first-class or upper second-class (2:1) undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
• Candidates applying to the 1-year MSc + 4-year PhD should hold or expect to hold a first-class or upper second-class (2:1) undergraduate degree or overseas equivalent
• University of Leicester English language (URL: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs ) requirements apply
Candidates who do not meet these entry requirements, but feel they have additional research experience should describe this clearly in the applicant statement.
Applicants should note that this programme is not intended for clinically active, medically qualified candidates.

Eligibility
UK/EU and International* applicants may apply.
*International applicants not applying from a Low or Middle Income Country must be able to demonstrate that they can fund the difference between UK/EU and International tuition fees for the duration of the PhD.

Enquiries
For project enquiries please contact the relevant Theme lead or the project supervisor in the first instance.

Administration and general enquiries to Sarah Robinson at [Email Address Removed].

To Apply
Please follow the application advice and submit your application using the online application form at
https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust-2020


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