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Genome behaviour in cellular senescence generated by different pathways


   Biosciences

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  Dr Joanna Bridger, Dr Kazunori Tomita  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Cells entering senescence in our bodies is responsible for age-related degeneration, diseases and illnesses, as well as a reduced life-span. Studies of senescence in culture requires primary cells that are induced to enter cellular senescence. However, we hypothesis that these methods using oncogenes, stress and enforced cell divisions do not give equivalent senescent states especially when assessing genome behaviour. Thus, this PhD project will compare chromosome and gene behaviour in the different types of senescence with assays that look at genome organisation - fluorescence in situ hybridisation and bio-imaging and analysis, chromosome conformation capture, epigenetics using chromatin immunoprecipitation and sequencing, gene expression via RNA seq and quantitative PCR and bioinformatics and the ability of new senotherapeutic drugs to rejuvenate senescent cells and repair any alterations to genome function in senescent cells.


Funding Notes

Brunel offers a number of funding options to research students that help cover the cost of their tuition fees, contribute to living expenses or both. See more information here: https://www.brunel.ac.uk/research/Research-degrees/Research-degree-funding. The UK Government is also offering Doctoral Student Loans for eligible students, and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.

References

Mehta et al., Interphase Chromosomes in Replicative Senescence: chromosome positioning as a senescence biomarker and the lack of nuclear motor-driven chromosome repositioning in senescent cells. (2021). Frontiers in Cell and Developmental Biology In press
Senescence and the Genome (2021). Foster and Bridger. In Human Interphase Chromosomes. Edited Ivan Iourov, Svetlana Vorsanova, Yuri Yurov

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