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Genome editing toward bacterial cell factories for synthesis and assembly of innovative materials

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Bacterial cell factories were developed to demonstrate production of tailor-made biopolymers such as polyesters and polysaccharides. However, these production strains often lack stability and hence are not suitable for scalable cost-effective production of these materials. Here, the CRISPR-Cas9 system will be used for inserting three genes required for biopolyester synthesis and assembly of functional protein-displaying beads into the genome of the endotoxin-free Escherichia coli strain for stable and improved production of protein-coated polyester beads to serve as vaccine, drug carrier or diagnostic reagents.

Funding Notes

About the Scholarship

The 2019 Griffith University Postgraduate Research Scholarship has an annual stipend of $27,596 (indexed) for a period of up to three years of full-time study. Please see the GUPRS Conditions of Award for more information: View Website

A successful International applicant will also be awarded a Griffith University International Postgraduate Research Scholarship to cover tuition fees for up to three years. Please see the GUIPRS Conditions of Award for more information: View Website

References

1. Barrangou, R.; Doudna, J. A., Applications of CRISPR technologies in research and beyond. Nature Biotechnology 2016, 34, 933.

2. Rehm, B. H. A., Bacterial polymers: biosynthesis, modifications and applications. Nature Reviews Microbiology 2010, 8, 578.

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