This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Most of the human genome is associated with an anthropomorphic trait or disorder. A large minority of the human genome is also known to bind transcription factors in different cellular contexts. But what molecular mechanisms are dysregulated in disease and trait variation? Spanning this gulf is essential for efficient and cost-effective drug target discovery. This project addresses a Grand Challenge of 21st Century Biology: how to assign causality – across the entire human genome – to molecular phenomena that explain disease risk. For example, predicting that a change in binding affinity of a factor to a specific site alters disease susceptibility.
This project would best suit an individual with a numerical and analytical background (physics, computer science, mathematics etc) or a numerate biologist. Required training will be provided.