University of Leeds Featured PhD Programmes
Peter MacCallum Cancer Centre Featured PhD Programmes

Genomic and metabolomic approaches to individualised antimicrobial therapy


Institute of Infection, Veterinary and Ecological Sciences

About the Project

Antimicrobial resistance (AMR) threatens almost the entirety of our healthcare system if we are no longer able to treat common infections, provide post-operative care or protect patients with chronic health conditions. The immediate priority is better antibiotic stewardship and individualised therapy to target the right antimicrobial at the right dose to the right patient. Doing so would be both clinically effective for the patienthelp prevent evolution of drug resistance in the community.

This project will use new omic methods to understand the biology of antimicrobial resistance and underpin new methods of individualised antimicrobial therapy. The project will study clinical samples of Gram-negative bacteria, such as Pseudomonas aeruginosa, from hospitals and large clinical trials where resistance has emerged. We want to be able to predict which infections will develop resistance and which remain susceptible to therapy The genome of the pathogen is likely to affect its ability to evolve resistance and you will investigate genomic features that may enable this. This may include the content of genes carried by a pathogen and hence its ability to metabolise or excrete antibiotics. To test this you will use mass spectrometry-based metabolomics to investigate the range and dynamics of metabolites produced by drug sensitive and resistant pathogens.

Your project will involve both wet-lab and computational analysis. You will be trained in microbiology, genomics and metabolomics, and the analysis of complex datasets that combine omic data, drug resistance phenotypes and clinical data. You will learn experimental design and the application of biological theory to real-world clinical problems. Training will be through formal courses, guided laboratory work and analyses, and through being part of large, vibrant research groups.

This project would suit someone with an interest in fundamental biology that addresses medical problems, and who wishes to develop critical thinking through a PhD.

To apply for this opportunity, please send your CV and 2 references to .

This opportunity will close once a suitable candidate has been found.

Funding Notes

The project is open to both European/UK and International students. It is UNFUNDED and applicants are encouraged to contact the Principal Supervisor directly to discuss their application and the project.

Details of costs can be found on the University website:
View Website

References

Williams, D., Fothergill, J. L., Evans, B., Caples, J., Haldenby, S., Walshaw, M. J., . . . Paterson, S. (2018). Transmission and lineage displacement drive rapid population genomic flux in cystic fibrosis airway infections of a Pseudomonas aeruginosa epidemic strain. MICROBIAL GENOMICS, 4(3). doi:10.1099/mgen.0.000167

Williams, D., Evans, B., Haldenby, S., Walshaw, M. J., Brockhurst, M. A., Winstanley, C., & Paterson, S. (2015). Divergent, Coexisting Pseudomonas aeruginosa Lineages in Chronic Cystic Fibrosis Lung Infections. American Journal of Respiratory and Critical Care Medicine, 191(7), 775-785. doi:10.1164/rccm.201409-1646OC

AlRabiah, H., Allwood, J.W., Correa, E., Xu, Y. & Goodacre, R. (2018) pH plays a role in the mode of action of trimethoprim on Escherichia coli. PLoS ONE 13: e0200272

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Liverpool will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.