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  Genomic approaches to understanding molluscan parasites


   School of Life Sciences

  Dr A Davison, Dr C M Wade  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Snails and slugs cause worldwide problems, both in terms of direct damage to crops, and as intermediate vectors for diseases of farm animals and humans (e.g. schistosomiasis). Yet, both snails/slugs and their parasites are frequently difficult to identify, and we have little idea of what influences their distributions, hindering appropriate control measures. Genomic techniques offer a potential solution in that they can be used to understand the relationship and taxonomy of different species, and, ultimately, the genes involved in enabling adaptation to human-affected environments.

In this project, the student will apply genomic methods to the pest snail/slug species and/or their parasites, with a view to putting together a general picture of their coevolutionary relationships.

The student will receive training in a wide range of transferable skills, starting with the standard laboratory techniques of molecular biology (DNA extraction, PCR, electrophoresis. These techniques will then be used to generate whole genome sequences for the species of interest, using a combination of Illumina, PacBio and Nanopore methods. In analysing the data, the student will receive training in bioinformatics. Field work will also be a necessary part of the main PhD, to collect specimens.

The project would suit a student who is keen to graduate with skills in a variety of techniques, making them employable in a breadth of fields.

Biological Sciences (4)

References

Davison A, Neiman M (2021a) Mobilising molluscan models and genomes in biology. Philos Trans R Soc Lond B Biol Sci 376: 20200163
Davison A, Neiman M (2021b) Pearls of wisdom – a special issue on molluscan genomics. Philos Trans R Soc Lond B Biol Sci 376: 20200151
Saadi AJ, Davison A, Wade CM (2020) Molecular Phylogeny of the Freshwater Snails and Limpets (Panpulmonata: Hygrophila). Zoological Journal of the Linnean Society 190: 518–531
Saenko SV, Groenenberg DSJ, Davison A, Schilthuizen M (2021) The draft genome sequence of the grove snail Cepaea nemoralis. G3 Genes|Genomes|Genetics 11: jkaa071
Joof E, Sanneh B, Sambou SM, Wade CM (2021) Species diversity and distribution of schistosome intermediate snail hosts in The Gambia. PLOS Neglected Tropical Diseases 15: e0009823

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