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Gentamicin Detection in Real Samples

   School of Chemistry

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Aminoglycosides, such as gentamicin, are important bactericidal agents with a broad spectrum of activity, with particular use in the treatment of serious gram-negative infections. They are key antibiotics recommended for use by WHO to combat rising global antimicrobial resistance. However, they require serum monitoring to guide dosing and prevent toxicity (e.g. nephrotoxicity and ototoxicity). Current techniques to measure the gentamicin concentrations are laborious, requiring skilled technicians and specialist equipment, with long turnaround times. This project will develop a lateral flow assay for detection of gentamicin.

The student will be based in the School of Chemistry at University of Birmingham (UoB). The multidisciplinary and translational research environment offered at the UoB is highly conducive to delivering this ambitious proposal. Equally, research centres such as the Institute of Translational Medicine will provide infrastructure to perform small-scale clinical trials for the proposed technology once a proof-of-principle has been demonstrated. Birmingham Health Innovation Campus aligns with the broader life sciences expertise across the West Midlands for improved treatment and patient care.

Applications from self-funded students are invited. No scholarships are available for this project. Interested candidates may contact Dr Gupta () for an informal discussion.

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