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Global burden and determinants of hypoglycaemia: epidemiological analyses of the Hypoglycaemia Assessment Tool (HAT) study


Project Description

Intensive glucose control results in higher rates of hypoglycaemia which negatively impacts the quality of life and prevents maintenance of a good glycaemic control. Risk factors for hypoglycaemia have been identified mainly for severe episodes in small cohorts of people with diabetes; it remains unclear, however, the impact of those factors on the absolute risk of hypoglycaemia; whether differences across geographical regions could be explained by phenotypical patients’ characteristics; or whether there are differences in the determinants of severe vs non-severe episodes of hypoglycaemia.

This PhD project will undertake a series of epidemiological analyses of the Hypoglycaemia Assessment Tool (HAT) study database, the largest global hypoglycaemia study collecting information on hypoglycaemia from 24 countries worldwide. The post holder will work to identify key patterns of hypoglycaemia and related factors, such as age, gender, glucose control, diabetes duration. The student will be embedded within a team of experts in clinical diabetes, epidemiology and statistics and receive training in a broad range of statistical methods used to investigate cross-sectional and longitudinal real-world data, as well as methods for prognostic research (development and validation of prognostic models).

The PhD project will be integrated into a vibrant postgraduate research community within the Real World Evidence Unit and the Diabetes Research Centre, University of Leicester and help advance the aims of the National Institute of Health Research Leicester Biomedical Research Centre (BRU) and East Midlands Collaboration for Leadership in Applied Health Research and Care (CLAHRC).

Entry requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

To apply please refer to: https://le.ac.uk/study/research-degrees/funded-opportunities/hs-zaccardi-novo-2020

Funding Notes

Registration Fees at home/EU rates for 3 years

Annual stipend at standard RCUK rates for 3 years

Research Training Support Grant (including travel allowance) of £2,500 per annum for 3 years

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