The lab of Dr. Philippe Campeau focuses on studying new skeletal dysplasias, new forms of epilepsy and chromatin remodeling disorders (www.pcampeaulab.org). We identify new disease-causing genes, understanding the pathological basis of disease, and try to improve the management of children affected by these conditions.
The tasks of the trainees will be to analyze exome and genome data to identify causative mutations. Then, the mutations will be introduced in expression vectors by standard molecular biology approaches, or in cell lines (such as induced pluripotent cell lines) by the CRISPR/Cas9 approach. In vitro, the effect of the mutations on the gene’s pathway will be assessed by a combination of analysis of RNA, protein and cell studies. These techniques include but are not limited to RNA-seq, ChIP-seq, ATAC-seq, and flow cytometry. In addition, the mutations may be introduced in muce also by the CRISPR/Cas9 approach, to eventually phenotype these mice to better understand the effect of the mutations.
Applicants should have extensive molecular biology experience in research labs, and provide simply a CV and university transcripts to Dr. Campeau at [email protected]. In compliance with Canadian immigration requirements, priority shall be given to Canadian citizens and permanent residents. The University of Montreal and the CHU Sainte-Justine Research Center (https://research.chusj.org) subscribe to equal opportunity hiring and invites women, members of visible minorities, members of ethnic minorities, individuals with handicaps and native people to apply.