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Great North Cancer Research JGW Patterson Foundation PhD Studentship in Cancer Research - Understanding the mechanisms of chromothripsis in cancer


Project Description

Number of awards:
1

Start date and duration:
October 2019 for 4 years.

Overview:
Are you interested in applying fundamental cell biology to understanding how cancer develops in real patients?

The genomes of cancer cells are often complex, with numerous mutations and chromosomal rearrangements. Chromothripsis (chromosome shattering) is a particularly interesting form of rearrangement in cancer, in which it looks like one or a few chromosomes have been smashed into hundreds of pieces, and then reassembled randomly. This distinctive profile suggests that it arises from DNA damage occurring after chromosome segregation errors during cell division. However, factors that predispose to chromothripsis and how chromothripsis arises in cancer remain unknown. You will use cutting-edge cell biology tools to study the first genuine patient-derived cell model of chromothripsis (iAMP21-Acute Lymphoblastic Leukaemia). The project brings together the expertise of the Higgins group in cell division with that of the Harrison group in leukaemia genetics, and will allow you to understand how chromothripsis arises and to determine what predisposes individuals to developing this form of cancer.

Sponsor:
JGW Patterson Foundation

Name of supervisor(s):
Professor Christine Harrison (https://bit.ly/2Uu4Nie), Northern Institute for Cancer Research (https://bit.ly/2Ig4b9D)
Professor Jonathan Higgins (https://bit.ly/2uZXf7R), Institute for Cell and Molecular Biosciences (https://bit.ly/2G9Uw0H)
Dr Diana Papini (https://bit.ly/2KKDtbl), Institute for Cell and Molecular Biosciences (https://bit.ly/2G9Uw0H)

Eligibility Criteria:
You must have, or expect to achieve, at least a 2:1 Honours degree in biomedicine, molecular or cellular biology or a related area. A further qualification such as an MSc or MRes is advantageous but not required.

This award is available to UK/EU and international applicants, but international candidates will be required to make up the difference between the UK/EU fees and international fees.

How to apply:
You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’ (https://bit.ly/2VG5j9m).

Only mandatory fields need to be completed. However, you will need to include the following information:

insert the programme code 8330F in the programme of study section
select ‘PhD in the Faculty of Medical Sciences – Cancer Research’ as the programme of study
insert the studentship code CR090 in the studentship/partnership reference field
attach a covering letter and CV. The covering letter must state the title of the studentship, quote the studentship reference code CR090 and state how your interests and experience relate to the project
attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.

Contact:
For further details, please contact:

Professor Jonathan Higgins
Institute for Cell and Molecular Biosciences (https://bit.ly/2G9Uw0H)

Funding Notes

100% of UK/EU tuition fees paid and annual living expenses starting at £15,347 (2019-20) annually, for the duration of the Programme. Successful international candidates will be required to make up the difference between the UK/EU fees and international fees. Also significant additional funding to cover research costs.

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