Gut on a Chip 4.0: next generation models to study gut-microbiome-metabolism interactions
Funded by the CDT in Chemical Biology: Innovation in Life Sciences – 1+3 year PhD studentships - APPLY HERE
Supervisors: Prof Gary Frost
Prof Joshua Edel
Dr Aylin Hanyaloglu
Prof Ed Tate
There is currently no readily accessible and realistic model for human gut signaling. Such a model would need to combine computational modelling with functional readouts in a physiologically relevant setting, in the presence of diverse metabolites and receptors in a dynamic microbiota environment, and under the influence of nutrition. This unsolved technological challenge holds back progress in understanding the roles of metabolite signaling for the treatment of obesity and metabolic disease. The aim of the PhD will be to deliver a new human colon microfluidic technology platform that will enable analysis of gut signaling in a near physiological setting, through a computational and physical model. To achieve this we will deliver a human in vitro colonic microfluidic model, complete with mechanically active bacterial microenvironment and neuronal system. This ambitious aim, which has never been achieved before, requires a highly inter-disciplinary PhD necessitating specialists in 4 main areas in order for the project to progress and succeed: device design and fabrication, GPCR biology, chemical probes, and organoid transfer to the device. Our industrial partner Emulate will play an active role in the PhD. We are seeking students to have a keen interest in advanced cell models and hands on experimental biology
By the end of the PhD the student will have delivered a near human colonic model which can be used to understand the complexed relationship between nutrition, microbiota and multidimensional GPCR signaling pathways.
Applications are encouraged as soon as possible, since positions will be filled as soon as suitable candidates are found.
To see our other projects, our eligibility criteria, and to find out how to apply, please visit our studentships page: View Website
How good is research at Imperial College London in Chemistry?
FTE Category A staff submitted: 54.90
Research output data provided by the Research Excellence Framework (REF)
Click here to see the results for all UK universities