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Applicants should have a strong quantitative background (a degree in Mathematics, Physics, Engineering, Computer Science)
IVF is the primary treatment of infertility with ~2.5 million treatments and ~500,000 births annually. The success rate has been ~25% for many decades but it has been decreasing while the IVF industry is projected to grow to 37.7 billion (USD) by 2027 with an ~10% annual growth rate. Success rates have been declining mainly because of culturing embryos for 5-6 days before selecting the ‘best' single embryo for transfer to the patient. This is not ideal because in vitro conditions never full mimic in vivo conditions. Moreover, the embryos take more of the clinic’s resources and the process is more psychologically taxing for the patient.
Τhis project will pave the way for providing the IVF clinics with a novel diagnostic tool that can revolutionise IVF practice: a rapid (day 1) quantitative indicator of embryo viability. This novel methodology is based on monitoring calcium (Ca2+) signalling in fertilising eggs and the associated egg movements and flows. The methodology was pioneered through a collaboration between the Swann lab (Cardiff Biosciences) and labs in Oxford and Cambridge in 2011 but has not progressed, partly due to the lack of accurate, sophisticated mathematical modelling and data analysis. A patent based on the latter experiments (granted to Cambridge Enterprise Ltd) has been allowed to lapse because of lack of quantitative progress.
The proposed PhD project will close the translation and innovation gap through advanced mathematical modelling, simulation, data analysis and AI.
Ca2+ waves and oscillations are integral in fertilization. There is an optimal Ca2+ pattern associated with successful IVF but monitoring Ca2+ damages the egg. It has, however, been recently observed that Ca2+ waves cause subtle movements (spasms) and flows in eggs; these could be detected non-invasively, through low-cost imaging, such as Particle Image Velocimetry. The coupling between Ca2+ waves and egg cytoplasmic movements will be elucidated in this project through mathematical modelling and data analysis. It is also unclear how to optimize the signal to noise for tracking egg movements as these vary over time and from one egg to another; the project will also tackle this challenge. This is an ambitious project at the forefront of smart, data-driven healthcare technologies and lies at the Mathematical Sciences/ Life Sciences interface..
The student will develop advanced mathematical modelling, coding and data analysis skills while benefiting from the collaboration with the Swann lab which is at the forefront of the IVF field. The student will also observe experiments on fertilizing eggs and guide data extraction. The student will employ sophisticated statistical methods to parametrise, validate and test the models. The student will, thus, communicate across Biology, Medicine and Mathematics generating predictions that can be used in further experiments. High-impact papers will be generated from the thesis and the student will present in international conferences as well as to experimental collaborators. At the end of the project the student will be able to pursue an exciting career in academia or in industry. The student will be based at Cardiff School of Mathematics (supervisors: Kaouri, Woolley) and co-supervised by Swann (Cardiff, Biosciences), Tsaneva-Atanasova (Exeter, Living Systems Institute), Hall (Bristol, Engineering Mathematics). They will join the vibrant community of Mathematical and Computational Biology and Medicine across these universities. Infertility challenges all countries and the work will have world-wide impact on a large community of scientists and patients. (For some references related to the project see the end of this advert.)
About the GW4 BioMed2 Doctoral Training Partnership
The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Students will have access to the combined research strengths, training expertise and resources of the four research-intensive universities, with opportunities to participate in interdisciplinary and 'team science'. The DTP already has over 90 studentships over 6 cohorts in its first phase, along with 58 students over 3 cohorts in its second phase.
Eligibility
Residency: The GW4 BioMed2 MRC DTP studentships are available to UK and International applicants. Following Brexit, the UKRI now classifies EU students as international unless they have rights under the EU Settlement Scheme. The GW4 partners have all agreed to cover the difference in costs between home and international tuition fees. This means that international candidates will not be expected to cover this cost and will be fully funded. All studentships will be competitively awarded and there is a limit to the number of International students that we can accept into our programme (up to 30% cap across our partners per annum).
Academic criteria: Applicants for a studentship must have obtained, or be about to obtain, a UK degree, or the equivalent qualification gained outside the UK, in an appropriate area of medical sciences, computing, mathematics or the physical sciences. Please check the entry requirements of the home institution for each project of interest before completing an application. Academic qualifications are considered alongside significant relevant non-academic experience.
English requirements: If English is not your first language you will need to meet the English language requirements of the university that will host your PhD by the start of the programme.
How to Apply
A list of all the projects and how to apply is available on our website at gw4biomed.ac.uk. You may apply for up to 2 projects and submit one application per candidate.
Please complete an application to the GW4 BioMed2 MRC DTP for an ‘offer of funding’. You may also need to make an application for an 'offer to study' to your chosen institution(s).
Please complete the online application form linked from the DTP’s website by 5.00pm on Monday, 4th November 2024. If you are shortlisted for interview, you will be notified from Friday, 20th December 2024. Interviews will be held virtually on 23rd and 24th January 2025. Studentships will start on 1st October 2025.
Further Information
For informal enquiries, please contact [Email Address Removed]
Before applying, you are strongly encouraged to contact Dr Katerina Kaouri for an informal discussion about the project.
This studentship is funded through GW4BioMed2 MRC Doctoral Training Partnership. It consists of UK tuition fees, as well as a Doctoral Stipend matching UK Research Council National Minimum (£19, 237 p.a. for 2024/25, updated each year).
Additional research training and support funding of up to £5,000 per annum is also available.
Studentships will be 4 years full time. Part time study may also be available.
international candidates need to be aware that they will be required to cover the cost of their student visa, healthcare surcharge and other costs of moving to the UK to do a PhD
Research output data provided by the Research Excellence Framework (REF)
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