Harnessing cell competition to boost tissue repopulation in stem cell therapies at University of Bristol on FindAPhD.com

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Dr Eugenia Piddini Applications accepted all year round Self-Funded PhD Students Only

Bristol United Kingdom Biophysics Cell Biology Developmental Biology Molecular Biology Systematic Biology

About the Project

Cell competition is a fundamental biological process akin to natural selection at the cellular level. Through this selection process, cells that are relatively less fit, mis-specified or that harbour some oncogenic mutations are eliminated, and hence called losers, when in proximity of fitter cells, termed winners. This results in the progressive elimination of the loser population and their replacement by winner cells, through active tissue colonization. Over the past decade our group has identified many novel molecular players that trigger cell competition. We now aim to harness these molecular tools to boost cell repopulation in regenerative medicine approaches, using several models of human organoid and stem cell cultures. You will establish conditions to discover how human organoid cells and stem cells compete to identify pathways and molecules that can be used in stem cell therapies to provide an advantage to donor stem cells and facilitate tissue repopulation

Webpage: https://piddinilab.org

Funding Notes

This project is available to international students who wish to self-fund their PhD or who have access to their own funding. Please contact the PGR administrators in the Faculty of Life Sciences for information about the project and how to apply ([Email Address Removed]).

Where will I study?

University of Bristol

The University''s outstanding reputation makes our students highly attractive to employers. Bristol is ranked joint seventh in the UK for graduate employability (QS Graduate Employability Rankings 2022).