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HDAC inhibitors: a potential therapy for breast cancer?

Project Description

Radiation resistance, due to hypoxia, remains a major cause of mortality in the treatment of breast cancer. Histone deacetylase inhibitors (HDACi) are currently in clinical trials for breast cancer and our preliminary data strongly suggest that HDACi are efficacious under hypoxia and therefore have the potential to overcome hypoxia induced breast cancer resistance to radiotherapy. The student will have the chance to investigate how HDACi will augment the efficacy of radiotherapy for the treatment of breast cancer in the presence or absence of hypoxia. Specifically this PhD project aims to investigate the effectiveness of HDACi and radiotherapy, singly and in combination, on proliferation, cell cycle, apoptosis, migration and DNA double strand breaks in breast cancer cell lines. The student will then investigate the mechanisms of these actions using a combination of signal array analysis, Western blotting and proteomics to establish whether HDACi alone or in combination with radiotherapy will affect multiple cellular pathways, including angiogenesis and apoptosis, in breast cancer cells. This research will culminate with an evaluation of whether HDACi will improve the efficacy of radiotherapy in pre-clinical models of breast cancer. The project will be supervised by a successful supervisory team with proven collaboration leading to all students having published.

Funding Notes

Funding notes:
Basic tuition fee and consumable costs must be covered by applicants.

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience. In addition candidates are expected to be proficient in English

Interested candidates should in the first instance contact Dr Carolyn Staton (Tel: +44 (0)114 2159063; email: )

How to apply:
Please complete a University Postgraduate Research Application form available here: View Website

Please clearly state the prospective main supervisor in the respective box and select ‘Oncology & Metabolism’ as the department.

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