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Health and Economic Impact of Viral Vaccinations on Antibiotic Use and Resistance

Project Description

2019-20 Medical Research Foundation National PhD Training Programme in Antimicrobial Resistance Research PhD Studentship

This fully-funded 3.5 year PhD studentship is available for an excellent candidate interested in researching the problem of antimicrobial resistance (AMR) in a cross-disciplinary manner.

Inappropriate usage of antimicrobials is a main driver of AMR. The majority of inappropriate antibiotic prescribing occurs in primary care, and predominantly due to self-limiting or viral respiratory tract infections (RTI). Therefore, there is large potential to reduce antibiotic prescribing and AMR by implementing viral vaccination programmes.

Recent studies have found that vaccinating children against influenza was associated with a reduction in antibiotic use. However, the subsequent possible impact on antibiotic resistance has not been quantified. Decisions on whether to introduce new or extent current vaccination programs are heavily influenced by cost-effectiveness models that completely ignore the potential impact of vaccinations on antibiotic use and AMR. This PhD will focus on developing methodologies and models that better incorporate the true costs and consequences of viral RTIs, including the costs associated with unnecessary antibiotic use and increased AMR. These models will be used to inform policy decisions in this high-priority area.

This PhD will be supervised by a multi-disciplinary team from Imperial College London, University of Oxford (Dr Koen Pouwels) and Public Health England (Dr Julie Robotham), with expertise in statistics, mathematical modelling, health economics, and AMR. This project will combine data analysis for epidemiological insight and transmission dynamic models incorporating economic principles. It creates a valuable opportunity to work in both academic and public health/policy environments and learn a unique skill set in an area where there is a shortage of health economists with mathematical and statistical modelling skills.

Potential applicants are encouraged to contact Dr Ceire Costelloe for informal discussion about the project prior to submitting a formal application.

Funding Notes

This fully-funded 3.5 year studentship covers:

• tuition fees (Home/EU rate)
• tax-free stipend (£17,000 in Yr 1 increasing by £500 per year, plus London weighting)
• research costs
• 3-month research project/placement allowance
• annual travel allowance

For more information on the Medical Research Foundation National PhD Training Programme in AMR, please see the Programme's website: View Website

Applicants must meet the Imperial College London’s research degree entry requirements. Applicants must have obtained, or be about to obtain, at least a 2.1 honours degree in a relevant subject, and should have training and experience in statistical or epidemiological methods.


How to apply
Applicants should submit an application including a CV and covering letter to [email protected]
The deadline for applications is midnight GMT on Friday 4th October 2019. Applicants short-listed for this funding will be interviewed by an academic panel from the AMR consortium at Imperial College London. Interviews will be held at Imperial College London.

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