About the Project
Research in the past decade has highlighted the broad benefits of pro-inflammatory trained immunity for host defence in the context of infectious disease; however, anti-inflammatory trained immunity could on the other hand have a protective influence against the development of immune-mediated diseases, of important therapeutic implications. Diseases mediated by a dysregulated immunity, such as inflammatory bowel disease, rheumatoid arthritis or asthma, are often treated with immunosuppressive drugs, which, although effective, are not voided of serious side effects. We have previously shown that immunomodulatory strategies that, instead of suppressing, promote the body’s natural protective innate immune responses can effectively ameliorate disease progression in models of inflammatory bowel disease.
Innate immune memory may also play a role in the connection between early life exposure to microbes and patterns of disease susceptibility. Of note, epidemiological studies reveal a significantly lower incidence of immune mediated diseases in developing countries with a high prevalence of parasite infections. Thus, it is possible that parasites could induce an anti-inflammatory training program in our immune system that may be key in preventing the development of those conditions.
This project aims to examine the hypothesis that helminth-derived products can effectively induce a training program in macrophages, reprogramming them to be more anti-inflammatory in response to a secondary inflammatory stimulus. A secondary aim in the wider project will be to establish if anti-inflammatory trained immunity induced by helminth products confines a reduced susceptibility to inflammatory bowel disease.
Rusek P, Wala M, Druszczyńska M, Fol M. Infectious Agents as Stimuli of Trained Innate Immunity. Int J Mol Sci, 2018; 19(2)
Garrido-Mesa N, Schroeder J-H, Stolarczyk E, Gallagher AL, Lo JW, Bailey C et al. T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function. Mucosal Immunology. 2019; 12(1):51-63
Garrido‐Mesa J, Rodríguez‐Nogales A, Algieri F, Vezza T, Hidalgo‐Garcia L, Garrido‐Barros M, et al. Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution. Br J Pharmacol. 2018; 175(23):4353-70.
Versini M, Jeandel P-Y, Bashi T, Bizzaro G, Blank M, Shoenfeld Y. Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications. BMC Medicine. 2015;13(1):81
Helmby H. Human helminth therapy to treat inflammatory disorders- where do we stand? BMC Immunology. 2015;16(1):12
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.
Investigation of the critical roles of platelets at the interface between thrombosis and inflammation in order to develop improved therapeutic strategies for the treatment and/or prevention of cardiovascular/inflammatory diseases
University of Reading