Earlier diagnostic/detection for diseases (cancer, chronic or foodborne) enables doctors making a rapid clinical decision, which considerably enhances the success of treatment and medical intervention and ultimately benefits to human health. Foodborne diseases have been a growing worldwide public health problem, which encompass a wide spectrum of illnesses, such as E-Coli, Salmonellosis, Listeriosis, and Gastroenteritis. To reduce the risk, high risk food products must be tested before being sold for consumption. The traditional technique for diseases earlier diagnostic is to culture diseases typically 1-2 days and then to do the test, which not only delays clinical decisions but also increases the cost. Hence, there is an urgent need to develop a high sensitivity, non-invasive biosensor for fast and early detection of diseases. The aim of this project is to develop a novel, high sensitivity, fast response and easy operating biosensor device that can manipulate and sense biomolecules, utilizing a fibre optic interferometry sensing technique integrated with multifunctional microfluidic systems.
The hypotheses of this project is that a tapered microstructure singlemode-multimode-singlemode fibre structure can achieve very high refractive index sensitivity. By proper surface functionalisation on the sensor, it can be used to detect very low concentration biological analytes. As an example for the application of the developed biosensor, it will be demonstrated for detection, identification and quantification of foodborne pathogens with very high sensitivity (10 CFU/mL) and fast response (<2 hours). To achieve this goal, we propose to integrate the sensor with microfluidic system for sample manipulation, mixing, separation, concentration and detection, where our collaborator, Prof. Nicole Pamme in University of Hull has extensive experience in microfluidic systems.
Academically strong candidates with BSc or Master’s Degree in Applied Physics or Optics or a closely related discipline are encouraged to apply. Experience in optoelectronics, optical fiber communications or optical sensing is desirable.
The principal supervisor for this project is Qiang Wu.
Eligibility and How to Apply:
Please note eligibility requirement:
• Academic excellence of the proposed student i.e. 2:1 (or equivalent GPA from non-UK universities [preference for 1st class honours]); or a Masters (preference for Merit or above); or APEL evidence of substantial practitioner achievement.
• Appropriate IELTS score, if required.
• Applicants cannot apply for this funding if currently engaged in Doctoral study at Northumbria or elsewhere.
For further details of how to apply, entry requirements and the application form, see https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please note: Applications that do not include a research proposal of approximately 1,000 words (not a copy of the advert), or that do not include the advert reference (e.g. RDF19/EE/MPEE/WU) will not be considered.
Deadline for applications: Friday 25 January 2019
Start Date: 1 October 2019
Northumbria University is an equal opportunities provider and in welcoming applications for studentships from all sectors of the community we strongly encourage applications from women and under-represented groups.
Dejun Liu, Rahul Kumar, Fangfang Wei, Wei Han, Arun Kumar Mallik, Jinhui Yuan, Shengpeng Wan, Xingdao He, Zhe Kang, Feng Li, Chongxiu Yu, Gerald Farrell, Yuliya Semenova and Qiang Wu, “High sensitivity optical fiber sensors for simultaneous measurement of methanol and ethanol”, Sensors and Actuators B: Chemical, vol. 271, 15 October, pp. 1-8, 2018 (Q1).
2. Peng Wang, Qiang Wu, Fuyan Wang, Yaping Zhang, Liying Tong, Tao Jiang, Chenjie Gu, Shuiping Huang, Hongxi Wang, Shizhong Bu & Jun Zhou, “Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy”, Nanomedicine (Future Medicine), vol. 13, no. 18, pp. 2245-2259, Oct. 2018 (Q1)
3. Fangfang Wei, Arun Kumar Mallik, Dejun Liu, Qiang Wu, Gang-Ding Peng, Gerald Farrell & Yuliya Semenova, “Magnetic field sensor based on a combination of a microfiber coupler covered with magnetic fluid and a Sagnac loop”, Scientific Reports, vol. 7, 2017 (Q1)
4. Lei Sun, Yuliya Semenova, Qiang Wu, Dejun Liu, Jinhui Yuan, Member, Tao Ma, Xinzhu Sang, Binbin Yan, Kuiru Wang, Chongxiu Yu, and Gerald Farrell, “High sensitivity ammonia gas sensor based on a silica gel coated microfiber coupler”, IEEE Journal of Lightwave Technology, pp. 2864-2870, vol. 35, no. 14, 2017. (Q1)
5. Guorui Zhou, Qiang Wu, Rahul Kumar, Wai Pang Ng, Hao Liu, Longfei Niu, Nageswara Lalam, Xiaodong Yuan, Yuliya Semenova, Gerald Farrell, Jinhui Yuan, Chongxiu Yu, Jie Zeng, Gui Yun Tian and Yong Qing Fu, “High Sensitivity Refractometer Based on Reflective Smf-Small Diameter No Core Fiber Structure”, Sensors, vol. 17, no. 6, 2017.
6. Youqiao Ma, Nghia Nguyen-Huu, Jun Zhou, Hiroshi Maeda, Qiang Wu, Mohamed Eldlio, Jaromír Pištora and Michael Cada, “Mach-Zehnder Interferometer-based Integrated Terahertz Temperature Sensor”, IEEE Journal of Selected Topics in Quantum Electronics, Jan. 2017 (Q1)
7. Tao Ma, Jinhui Yuan, Lei Sun, Zhe Kang, Binbin Yan, Xinzhu Sang, Kuiru Wang, Qiang Wu, Heng Liu, Jinhui Gao, and Chongxiu Yu, “Simultaneous measurement of the refractive index and temperature based on microdisk resonator with two whispering-gallery modes”, IEEE Photonics Journal , vol. 9, no. 1, 2017 (Q1)
8. Dejun Liu, Wei Han, Arun Kumar Mallik, Jinhui Yuan, Chongxiu Yu, Gerald Farrell, Yuliya Semenova, and Qiang Wu, “High sensitivity sol-gel silica coated optical fiber sensor for detection of ammonia in water”, Optics Express, Vol. 24, no.21, pp. 24179-24187, 2016 (Q1)
9. Arun Kumar Mallik, Dejun Liu, Vishnu Kavungal, Qiang Wu, Gerald Farrell and Yuliya Semenova, “Agarose Coated Spherical Micro Resonator for Humidity Measurements”, Optics Express, vol. 24, no. 19, 21216-21227, 2016 (Q1)
10. Dejun Liu, Arun Kumar Mallik, Jinhui Yuan, Chongxiu Yu, Gerald Farrell, Yuliya Semenova, Qiang Wu, “High sensitivity refractive index sensor based on a tapered small core single-mode fiber structure”, Optics Letters, vol. 40, no. 17, pp. 4166-4169, 2015 (Q1)