Space in the capsids of small viruses is limited and small viruses do not encode every enzymatic activity required for their replication. Single stranded plus RNA (+RNA) viruses like picornaviruses or flaviviruses replicate at replication organelles (also known as replication factories or membranous webs) which provide an optimal replication environment and also protection from innate immunity. To create these replication organelles +RNA viruses “hijack” a plethora of host factors such as the lipid kinase PI4KB or the Golgi-resident ACBD3 protein. The aim of this project is to structurally characterize complexes of viral and human proteins to gain deep molecular understanding and to define new targets for antivirals.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications