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HiSCORE - Highly Informative Drug Screening by Overcoming NMR Restrictions


   Department of Chemistry

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  Prof Geoffrey Bodenhausen  Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

Our recently funded ERC Synergy Grant seeks to advance hyperpolarisation, miniaturisation, parallelisation and spin dynamics, and combine these research themes for highly informative drug discovery by nuclear magnetic resonance. We believe that, eventually, magnetic resonance can provide an in- depth biophysical characterisation of drug candidates in a much shorter time than today, and become a very effective platform for rapid drug discovery.

This interdisciplinary project is run by four laboratories (Geoffrey Bodenhausen, Arno Kentgens, Jan Korvink, and Benno Meier) in three institutions (ENS Paris, Radboud University Nijmegen, and Karlsruhe Institute of Technology). Our partners Alvar Gossert (ETH Zürich) and Claudio Dalvit (Trento) complete our team with strong expertise in magnetic resonance (MR) based drug discovery.

Due to the word limits, please refer to the attachement here for full information.

To apply for the PhD position, please combine your CV, a motivation letter, and reference letters (if available) into a single PDF, and upload it below.

Some relevant references are given here:

  1. Ligand−Protein Affinity Studies Using Long-Lived States of Fluorine- 19 Nuclei
  2. From single to multiple microcoil flow probe NMR and related capillary techniques: a review
  3. Microcoil nuclear magnetic resonance spectroscopy
  4. Adiabatic Solid Effect
  5. Characterization of Chemical Exchange Using Relaxation Dispersion of Hyperpolarized Nuclear Spins
  6. Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization

Funding Notes

This is a fully funded PhD position (for all nationalities and disclipines). The candidate has to choose to one out of four supervisors, but expected to work with the other three supervisors.

References

1. https://www.ens.psl.eu/actualites/hiscore-mettre-profit-les-decouvertes-les-plus-innovantes-de-la-rmn-pour-trouver-de
2. https://analytik.news/en/press/2020/225.html
3. https://www.ru.nl/science/magneticresonance/news/erc-synergy-grant-2020/
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