About the Project
The urothelium is the self-regenerating epithelium that lines the bladder, where it is highly specialised to function as a urinary barrier. Although normally a mitotically-quiescent tissue, urothelium shows a rapid and highly regenerative response to damage. Whether there is a specific progenitor or stem cell population remains controversial, as no such cell has been unequivocally identified. An alternative hypothesis is that all cells remain capable of switching into a regenerative phenotype, irrespective of differentiation state. The project will examine this hypothesis in a well-established cell culture system, using a combination of cell and molecular biology approaches to examine the role of cell:cell interactions, downstream signal transduction and epigenetic regulation.
This is a self-funded project. Applicants need to have adequate funds to meet the costs of a self-funded research project including tuition fees and living expenses for the duration of the research programme. Please see information on tuition fee costs, living expenses and funding opportunities.