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Hormone regulation of fungal pathogenicity

  • Full or part time
  • Application Deadline
    Friday, April 17, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Candida albicans is an commensal yeast residing in the oral, gastrointestinal and urogenital tracks in up to 80% of the population. However, during periods of immune suppression, dysbiosis and changes in the host environment, C. albicans can proliferate causing mucosal as well as life-threatening systemic infections. The ability of C. albicans to sense and adapt to a changing environment is key to the pathogenicity of the organism. Changes in the host environment can promote the yeast to hyphal switch of C. albicans, a key virulence determinate of the fungus, but more recently environmental adaptation of C. albicans has been shown to promote fungal cell wall remodelling permitting the fungus to modulate the host-pathogen interaction. This PhD project will expand our knowledge of fungal innate immune evasion, through investigating how adaptation of C. albicans to human hormones enables the fungus to evade the innate immune and cause infection. In this project you will develop skills in molecular biology, host-pathogen interaction studies, FACS, ELISA, proteomics and super-resolution microscopy.

The candidate: We are looking for a highly motivated student with a minimum of 2:1 degree in a Biosciences-related
subject. A Master’s degree in a related subject is desirable.

How to apply: When applying, students should follow the University of Kent’s online application process:

As part of the process, students should include the following:

1.specify the project they wish to apply for;
2.explain reasons for study;
3.provide details/evidence of qualifications;
4.provide two academic references;
5.provide other personal information and supporting documentation.

Students should apply for the PhD in Microbiology. Deadline for applications:17 April 2020.

Funding Notes

The studentship is funded by the Graduate Teaching Assistantship (GTA) which provides financial support in return for 96
hours of teaching per year. The stipend paid equals the full UK Research Council rate of £15,009 (rate for 2019/20) plus tuition fees at the Home/EU rate. International applicants should make provision to meet the difference between Home/EU and International fees

How good is research at University of Kent in Biological Sciences?

FTE Category A staff submitted: 24.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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