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Host-Microbe Interactions in Ventilator-Associated Pneumonia


Project Description

This project will investigate the role of commensal and pathogenic microorganisms in the aetiology progression, diagnosis and antimicrobial therapy of ventilator-associated pneumonia (VAP) in intensive care patients. The project will ask how we can best predict, diagnose and treat VAP by investigating the host-microbe interactions involved in the progression of the disease.

VAP, a common hospital-acquired infection, is associated with colonisation of endotracheal tubes in intubated patients and has a high mortality rate. In order to investigate the complexities of the disease, the project will take a ‘host-microbe interaction’ approach, investigating both microbial and host response factors.

VAP-associated microorganisms will be phenotypically characterised, investigating, among other factors, virulence and antimicrobial resistance (AMR). Mobile genetic elements linked to antimicrobial resistance will also be sequenced using third-generation sequencing technology. The host response to bacteria linked with VAP will be investigated in cell culture and tissue culture models using state-of-the-art assays.

The primary supervisor of the project will be Dr Joe Latimer, lecturer in antimicrobial resistance. The project will be co-supervised by Dr Ian Goodhead, lecturer in infectious disease and Dr Sarah Withers, lecturer in physiology. The project benefits from close collaboration with Salford Royal Foundation Trust.

For more information on research within the School of Environment and Life Sciences please visit the School research website http://www.salford.ac.uk/environment-life-sciences/research

Funding Notes

We welcome applications from Home/EU and Overseas self-funded students and those seeking their own funding from external sources who meet the entry requirements and are able to cover all the costs, including tuition fees, research costs and living expenses.

Informal inquiries can be made to Dr Joe Latimer () with a copy of your curriculum vitae and cover letter.

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