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How can epigenetic changes be used to predict and prevent cancer?

Project Description

Our lab, led by international leader in epigenetics Dr Aniruddha Chatterjee, combines cutting edge next-generation sequencing, computational analysis, and experimental work to decipher the role of epigenetic modifications and cellular phenotype in cancer. Early detection of cancer is key to improving survival, and improved monitoring of cancer treatments can detect emergent resistance at early stages of treatment, enabling timely switching of therapy.

This project will involve integrative analysis of genome-wide data from multiple cancer types, including colorectal cancer and melanoma, to identify early biomarkers for cancer occurrence and to predict the risk of metastasis and response to therapy. Lab-based work will use established molecular biology techniques, such as FACS and next generation sequencing, combined with cutting-edge molecular biology tools, such as single-cell epigenomic and transcriptomic profiling and CRISPR editing. Data analysis will also use a combination of standard bioinformatic tools and customised in-house pipelines.

This project is an excellent opportunity to be involved in a high quality multi-disciplinary team. The prospective candidate will learn a range of valuable skills and gain both ’wet’ and ’dry’ lab expertise while enjoying a great post-graduate experience in beautiful New Zealand.

Funding Notes

The successful candidate will have obtained a BSc(hons), BBioMedSci(hons) or MSc with high academic excellence. Knowledge of the following areas would be desirable: genetics/epigenetics, molecular biology and bioinformatics. However, consideration will be given to the potential of the student rather than just these mentioned skill sets. The prospective candidate needs to obtain a University of Otago PhD scholarship (it is competitive), for which the Principal Investigators of the project will provide support to the selected candidate. Please apply to Dr Chatterjee with your CV (including contact details of three references) and a single PDF containing the transcripts for academic qualifications.

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