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How chromatin structure affects genome editing and DNA repair

  • Full or part time
  • Application Deadline
    Friday, April 19, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.

Project details

Genome editing tools such as CRISPR-Cas9 allow the genetic code to be re-written inside living cells. In order to edit DNA, Cas9 must first identify the target site and break the double helix, after which sequence edits are introduced during the repair process. This project will investigate how chromatin structure, which controls the accessibility of chromosomal DNA to Cas9 and DNA repair factors, affects the efficiency of genome editing, the frequency of unwanted off-target mutations, and the outcome of DNA repair.

For further information on how to apply for this project, please visit: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-human-genetics

Funding Notes

For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.

However, EU students with quantitative or multidisciplinary skills are eligible for full funding.

Related Subjects

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