How do cancer mutations affect protein complexes?

This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.

Project details:

Protein complex assembly is often dysregulated in cancer due to mutations that directly affect protein sequence or cause stoichiometric imbalances. This project will combine genomic and proteomic datasets with a variety of computational approaches, including structural bioinformatics, molecular modelling and machine learning, to systematically study the ways in which cancer-associated mutations affect protein complexes, and compare them to the genetic variation observed in humans and across evolution. The ultimate goal is to identify features of proteins and complexes that explain the phenotypic effects of mutations, and can be used to computationally predict cancer driver mutations from high-throughput sequencing data.

For further information on how to apply for this project, please visit:https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-quantitative-scientist