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How do cells generate functional asymmetries?

  • Full or part time
  • Application Deadline
    Friday, January 11, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

The lab (https://www.staff.ncl.ac.uk/josana.rodriguez/) enjoys state of the art equipment and is situated in the ambitious and supportive research environment of the Institute for Cell and Molecular Biosciences (https://www.ncl.ac.uk/camb/), within the Medical School at Newcastle University (Newcastle upon Tyne, UK). We are part of a vibrant scientific community studying cell division from different angles (https://research.ncl.ac.uk/celldivisionbiology/).

We are seeking an enthusiastic and highly motivated student keen to investigate the fundamental principles of cell polarity establishment and asymmetric cell division, both essential to tissue and organ development. Therefore when cell polarity is perturbed it can lead to a wide-range of health problems including, cardiovascular diseases, neurodegenerative disorders, cancer and be detrimental to complex processes such as ageing. We have recently uncovered a novel cross-talk regulation/cooperation between key effectors of cell polarity, the PAR proteins. This project will reveal the dynamics and molecular mechanisms underlying this PAR-protein functional cooperation. We will use a multi-disciplinary approach, including genetic screens, proteomics, biochemical assays, genome editing, mathematical modelling and cutting-edge microscopy analyses (super-resolution). The project will use mainly the nematode C. elegans as a model, but mammalian systems are also available in the lab.

For further information see the website: http://www.ncl.ac.uk/camb/

To apply

Please complete the online application form and attach a full CV and covering letter. Informal enquiries may be made to

Funding Notes

This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,777 for 2018-19). The PhD will start in October 2019. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.

References

Rodriguez J et al. aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity. Dev. Cell, 2017 vol 42 (4): 400-415.

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