Our bones have many essential roles in our lives, including weight-bearing, ion homeostasis and allowing locomotion by anchoring the muscles. During childhood they must fulfill these functions as well as one more: they must grow so that we reach our adult height. The PhD student will study how the long-bones grow and aim to understand what maintains this growth throughout childhood.
The successful candidate will plan and conduct experimental research to reveal fundamental mechanisms of human growth. Duties will include collecting human and mouse growth plate samples and using molecular biology techniques to analyse them. Methodologies include sequencing experiments at the genomic and transcriptomic levels (RNAseq and spatial transcriptomics), confocal microscopy, laser capture micro-dissection, histological and histochemical staining, immunofluoresence, in situ hybridisation and other molecular biology technologies.The student will learn how to conduct bioinformatic analyses of their generated data.
The successful applicant will acquire basic and specialized knowledge and understanding of skeletal growth, stem cell renewal, and computational analyses.
Full details and a link to the application portal can be found using the following link: https://kidoktorand.varbi.com/en/what:job/jobID:376902/.
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