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How do malaria parasites sense and respond to DNA damage?


Department of Pathology

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Dr C Merrick No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

The malaria parasite Plasmodium has a complex lifecycle involving several highly unusual cell cycles. Rather than conventional binary fission, it grows via syncytial modes of replication, producing multinucleate syncytia prior to budding and cytokinesis. This presumably requires unusual, sophisticated regulators of DNA replication, DNA repair and cell-cycle checkpoints, yet these are very poorly understood. The current first-line antimalarial drug, artemisinin, can cause DNA damage and drug-resistant parasites have recently arisen. Their resistance apparently involves parasite ‘dormancy’ - possibly via a cell-cycle checkpoint. This project will investigate how Plasmodium responds to DNA damage and how this may be linked to artemisinin resistance.

Full details of the projects and how to apply are available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-studentships .
*Please quote reference PK17049 on your application and in any correspondence about this vacancy.

Funding Notes

The studentships are available to students who qualify for Home/EU fees. Further information at: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status.

Funding will cover the student's stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility with the possibility of additional funding in the fourth year depending on circumstances.

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject.
By time of interview all potential students must have fulfilled language requirements for admission.
(http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements).

Applications from ineligible candidates will not be considered.
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