About the Project
Training/techniques to be provided:
The post requires that a Home Office Personal Licence is obtained (following a provided Training Course) and that the candidate undertakes certain in vivo procedures. Full training is provided in these areas (and those below) and the candidate will be part of a large and highly experienced team.
Cell isolation by enzymatic digestion, cellular assessment of intracellular calcium concentration using confocal and epifluorescent microscopy, qPCR, cloning, Western blotting, immunohistochemistry, biochemical assays including ELISA and radio-ligand binding assays.
This project has a Band 3 fee. Details of our different fee bands can be found on our website (https://www.bmh.manchester.ac.uk/study/research/fees/). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/).
Informal enquiries may be made directly to the primary supervisor.
2. Anderson SG, Hutchings DC, Woodward M, Rahimi K, Rutter MK, Kirby M, Hackett G, Trafford AW, Heald AH. Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality. Heart. 2016
3. Horn MA, Bode EF, Borland SJ, Kirkwood GJ, Briston SJ, Richards MA, Dibb KM, Trafford AW. Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model. J Gerontol A Biol Sci Med Sci. 2015
4. Clarke JD, Caldwell JL, Horn MA, Bode EF, Richards MA, Hall MCS, Graham HK, Briston SJ, Greensmith DJ, Eisner DA, Dibb KM, Trafford AW. Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current. J Mol Cell Cardiol. 2015;79:169-179
5. Briston SJ, Dibb KM, Solaro RJ, Eisner DA, Trafford AW. Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes. Cardiovasc Res. 2014;104:347-354
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.
Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
University of Oxford