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How does crosslinking of the platelet receptors GPVI and CLEC-2 lead to activation and cleavage?

Institute of Cardiovascular Sciences

About the Project

Crosslinking of the glycoprotein receptors, GPVI, CLEC-2 and PEAR1, leads to activation of platelets through Src kinase dependent mechanisms. Activation of GPVI also leads to its cleavage by the transmembrane protein ADAM10. The aim of this project is to determine how crosslinking of GPVI, CLEC-2 and GPVI leads to platelet activation, and in the case of GPVI, cleavage.
We hypothesise that crosslinking of all three receptors generates a critical density of tyrosines in the inner leaflet of the membrane for phosphorylation by Src kinases. The aim of this project is to develop a computer model based on this hypothesis and to test this using protein chemistry and microscopy data generated within the group. The project is suitable for mathematicians, physicists, computer scientists or related disciplines. They will join a multi- and inter-disciplinary group focussing on platelet activation by GPVI and CLEC-2. As a member of the group, they will have the chance to generate biological data if they wish to do so.

Information enquiries to Steve Watson (), Mike Tomlinson () or Dylan Owen ()

Funding Notes

The project is suitable for self-funded students

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