Coventry University Featured PhD Programmes
Engineering and Physical Sciences Research Council Featured PhD Programmes
European Molecular Biology Laboratory (Heidelberg) Featured PhD Programmes

How does crosslinking of the platelet receptors GPVI and CLEC-2 lead to activation and cleavage?


Institute of Cardiovascular Sciences

About the Project

Crosslinking of the glycoprotein receptors, GPVI, CLEC-2 and PEAR1, leads to activation of platelets through Src kinase dependent mechanisms. Activation of GPVI also leads to its cleavage by the transmembrane protein ADAM10. The aim of this project is to determine how crosslinking of GPVI, CLEC-2 and GPVI leads to platelet activation, and in the case of GPVI, cleavage.
We hypothesise that crosslinking of all three receptors generates a critical density of tyrosines in the inner leaflet of the membrane for phosphorylation by Src kinases. The aim of this project is to develop a computer model based on this hypothesis and to test this using protein chemistry and microscopy data generated within the group. The project is suitable for mathematicians, physicists, computer scientists or related disciplines. They will join a multi- and inter-disciplinary group focussing on platelet activation by GPVI and CLEC-2. As a member of the group, they will have the chance to generate biological data if they wish to do so.
INTERESTED APPLICANTS SHOULD SEND THEIR C.V. TO PROF STEVE WATSON
.

Information enquiries to Steve Watson (), Mike Tomlinson () or Dylan Owen ()

Funding Notes

The project is suitable for self-funded students

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Birmingham will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.