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How does physical activity influence the efficacy of anti-cancer therapy? Investigating relationships between exercise, tumour activity and immunity in blood cancers.


Project Description

SUMMARY OF PROJECT

In recent years, it has become clear that physical activity and other related lifestyle factors such as body composition can influence the success of cancer treatment outcomes. It is proposed that immune modulation from exercise is a key driving force in eliciting these anti-tumour effects. This interdisciplinary project will examine how lifestyle interventions, such as undertaking regular exercise, influence treatment outcomes in people with blood cancers, including multiple myeloma. Specifically, the project will assess the interplay between exercise, immunity, and tumour activity throughout anti-cancer therapy. In addition, this project will examine if other lifestyle factors predict how successful therapy is (e.g. body composition, diet). Understanding the relationship between these risk factors and cancer is needed to better prescribe healthy living guidelines for patients, and to identify new disease pathways to help prevent and treat cancer.

THE RESEARCH PROJECT

If successful, you will undertake a systematic programme of research that will examine relationships between physical activity – as well as other lifestyle factors, such as body composition – in blood cancers such as multiple myeloma.

To achieve this aim, you will conduct cross-sectional, longitudinal and/or intervention studies which incorporate immunology, oncology, physiology and biochemical measurements.

You will gain expertise in a number of cutting-edge biochemical and immunological techniques, including multi-parameter flow cytometry, and will emerge with experience in the diagnosis and monitoring of blood cancers.

In addition to gaining a repertoire of contemporary and advanced skills important for an academic or industrial career in science, you will start to establish a track record in a research area that will remain a worldwide priority for the foreseeable future.

APPLICATION CRITERIA

Applicants for a studentship must have obtained, or be about to obtain, as a minimum, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an area appropriate to the skills requirements of the project.

Anticipated start date: April 2019

INTERVIEWS

Shortlisted candidates are likely to be interviewed the week commencing 4th March 2019.

Funding Notes

Jointly funded by Royal United Hospitals Bath NHS Foundation Trust and the University of Bath, this studentship will cover Home/EU tuition fees, an annual stipend (£14,777 (18/19 rate) and a training support fee for a period of up to 3 years for full time study.

How good is research at University of Bath in Sport and Exercise Sciences, Leisure and Tourism?

FTE Category A staff submitted: 22.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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