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How does the vascular matrix environment influence platelet activation?

   Hull York Medical School

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  Dr S Calaminus  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The platelet is a blood cell that plays a key role in the prevention of bleeding. For platelets to form a clot or thrombus effectively, they must rearrange their actin cytoskeleton to withstand high shear stress from blood flow in the arteries. This process depends on the environment of the artery as platelets change behaviour in response to matrix type, concentration and stiffness.
Intracellular cyclic nucleotide messengers cAMP and cGMP reverse platelet activation and alter the platelet actin cytoskeleton, causing thrombus instability under high shear stress. But exactly how this response is controlled by specific extracellular matrix characteristics is unknown. We hypothesise that the type, concentration and stiffness of specific matrix proteins alter platelet responses to cyclic nucleotide signalling to affect thrombus stability and structure. To test this hypothesis, you will use a combination of immunobiological approaches, imaging and functional assays to examine how matrix proteins modulate cyclic nucleotide signalling in human platelets. This will reveal new insights into how the platelet environment controls thrombus development.
This is a full time PhD in Medical Sciences.
For informal inquiries, please contact Dr. Simon Calaminus ([Email Address Removed]).
Location and Research Culture
Hull York Medical School’s unique partnership brings together the expertise of both the Universities of Hull and York and offers a thriving environment in which to conduct world-leading research. Strong partnerships with NHS Trusts and community health organisations offer a wide clinical base within which to study those conditions which most affect our communities – improving their health while developing research work that can be applied nationally and globally.
The School’s academic and clinical researchers at have a strong reputation for their work, 85% of which is classed as ‘world-leading’ or ‘internationally excellent’ (REF 2014). Their research is advancing improvements in healthcare – treatment, diagnosis and care – improving the health of people locally and impacting national and international health agendas.
The student will join a dynamic research team and thriving community of graduate students from the UK and overseas in the Centre for Atherothrombosis and Metabolic Disease at the University of Hull. Many students also study in our laboratories at local hospitals across the city. This gives our students unparalleled access to the facilities, academic and clinical expertise to thrive in their research.
Named Academic
Dr. Simon Calaminus, Senior Lecturer in Biomedical Science, Centre for Atherothrombosis and Metabolic Disease.
Email: [Email Address Removed]

Start Date
To be arranged upon acceptance of an offer.
Qualification Required
In order to qualify for this position, you will require an undergraduate degree with at least a 2.1, or equivalent, in a relevant subject (Biochemistry, Molecular and Cellular Biology, Pharmacology, Pharmacy or related discipline). English Language IELTS 6.5 with a minimum of 6.0 in all components.
How to Apply
All applications MUST be submitted through the HYMS Postgraduate Centre via the online application system:
Please apply for a “PhD in Medical Sciences” at Hull York Medical School. Please quote HYMS with the project title when applying. In order for the Panel to get a sense of your academic background, commitment and interest, you are required to complete the application form in full and provide a research proposal/outline of academic interest. Research proposals and personal statements may be used in selecting applicants for interview. If you have any queries on how to apply, please email [Email Address Removed].
Interview Date
Applicants who are shortlisted for interview will be sent details of the date, time and venue via email. If you are not invited for interview, it means that your application has not been successful. Please note that we do not offer feedback to applicants who are not invited to the interview.

Funding Notes

If you have the correct qualifications and access to funding through an external funded scholarship, your application will be considered.
In addition to tuition fees and living expenses, funding must also include a £6,000 per year Research Training Support charge over three years to cover costs of experimental work.
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