The assessment of percutaneous absorption of molecules is a very important step in the evaluation of any transdermal drug delivery system. The most reliable skin absorption data are obtained in human studies in vivo and human skin in vitro. However, the former studies are virtually impossible due to ethical difficulties and high cost. Hence the development of membrane systems which could mimic human skin and precisely predict transdermal delivery is of great interest and importance in industrial, regulatory, and academic circles. In this project, we shall investigate 3D reconstructed human skin as an alternative to human skin in the application on transdermal drug delivery. Different techniques and analytical methods will be explored for the investigation.
This project will be of considerable value in the assessment of model systems and for the candidate drugs of potential commercial importance. These outcomes should be of considerable scientific and commercial value.