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How is blood pressure controlled by the nervous system?

Project Description

The cardiovascular system is strongly influenced by the activity of the sympathetic nervous system. In disease conditions (such as hypertension and heart failure) the sympathetic system is overactive. There is growing interest in controlling this overactivity to treat such diseases, but not enough information on how to do this. To advance this knowledge, this project will investigate connections in the nervous system in relevant circuits. Targeting neuronal tracing using the latest viral vector technology will identify the anatomy of the circuits in mice. Functional circuit analysis will be conducted using 2-photon microscopy in slices of the CNS from transgenic mouse lines. Select circuitry will be activated using optogenetics. The initial focus will be on GABAergic cells, but this could expand to other cell types if time permit. Training will therefore likely include neuroanatomical tracing, immunohistochemistry, confocal microscopy, 2-photon calcium and voltage imaging and optogenetics.

Funding Notes

The Faculty of Biological Sciences is pleased to announce a number of fully-funded PhD studentships to start in Oct 2019, covering academic fees at UK/EU level and providing a stipend at research council rate (£15,009 for 2019-20) for 4 years. Candidates should have, or be expecting, a 2.1 or above at undergraduate level in a relevant subject. A range of projects, spanning the research areas of the faculty, are eligible for funding. Please apply online, clearly stating which project/supervisor you are interested in and including a CV and transcripts.

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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