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How to build a biological decoder – dissecting calcium specificity in plants (MILLERBU20SCIEC)


Project Description

Calcium is one of the most common secondary messengers involved in cell signalling in plants. A first response to a vast array of abiotic and biotic stresses includes changes in cytosolic calcium concentrations that regulate downstream processes. That so many processes seem to be governed by the change in the concentration of calcium has given rise to what has been called the calcium specificity problem: how can one ion species be responsible for conveying such diverse developmental processes and differentially active different pathways? 

The aim of this PhD project is to develop a deeper understanding of how calcium signals are interpreted by cells and decoded into specific biological responses in plants. The project will focus on a calcium- and calmodulin-dependent protein kinase from the model legume Medicago truncatula, and will study the mechanisms by which this protein is regulated by calcium and how this allows the decoding of specific calcium signals. 

This project will combine molecular biology, biochemistry and mathematical modelling, and will provide the student with excellent opportunities for multi-disciplinary training in plant molecular genetics and biochemical techniques, as well as computational modelling approaches. 

For more information on the supervisor for this project, please go here https://people.uea.ac.uk/b_miller
This is a PhD programme.
The start date of this project is 1 October 2020.
The mode of study is full-time.
The studentship length is 4 years.


Entry requirements:acceptable first degrees are Biological Sciences, Biochemistry, Chemistry or Mathematics. 

The standard minimum entry requirement is 2:1.

Funding Notes

This PhD project is in a competition for a Faculty of Science funded studentship. Funding is available to UK/EU applicants and comprises home/EU tuition fees and an annual stipend of £15,009 for 3 years. Overseas applicants may apply but they are required to fund the difference between home/EU and overseas tuition fees (which for 2019-20 are detailed on the University’s fees pages at View Website . Please note tuition fees are subject to an annual increase).

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