How to prevent promiscuous gene regulation
Regulatory elements that turn genes ON or OFF are promiscuous and can act over large genomic distances.
How are genes protected from unwanted regulation?
We address this problem by studying insulation - an activity exerted by dedicated DNA elements (“insulators”) and proteins (“insulator-binding proteins”) to protect genes from unwanted regulation. Defects in insulation can lead to malformations and disease caused by mis-regulation of key developmental genes. The mechanism of insulation is enigmatic, but it is currently believed to act at the level of chromosome folding or organization in the nucleus. We study insulators and insulator-binding proteins in Drosophila melanogaster as a genetically tractable model and in mammalian tissue culture cells, to understand the evolutionarily conserved basis of insulation.
We use multidisciplinary approaches including genetics (genome-engineering, analyzing mutant Drosophila), biochemistry (proteomics, structural biology), genomics (RNA-seq, ChIP-seq, chromosome conformation capture, genome-wide screens) and live-imaging.
We are looking for a motivated and capable member to join our international team to work on a competitive project.
INTERESTED? Contact me for more information about the project.
Fully funded position available, but you will be encouraged to try to apply for your own funding too.
You will be enrolled in a PhD school of the University of Lausanne (possible schools are Schools of Quantitative Biology, Molecular Life Sciences or others).