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  Hybrid antioxidant nanocarriers for the treatment of Alzheimer’s disease


   Faculty of Biology, Medicine and Health

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  Dr Christos Tapeinos, Prof Jayne Lawrence  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Alzheimer’s disease (AD) is a neurodegenerative disorder that yearly affects 50 million people worldwide, a number estimated to grow to 139 million in 2050. Although the reasons for AD’s pathogenesis are unknown, characteristics of the diseased microenvironment, like oxidative stress and neuroinflammation, are considered responsible for its development and progression. Although several FDA-approved medications alleviate the disease’s symptoms, most demonstrate low therapeutic efficacy. Among several reasons for this low efficacy is the low amount of therapeutics reaching the brain due to the blood-brain barrier (BBB) and the inflamed and hypoxic microenvironment that sustains and promotes the disease. The key hypothesis is that hybrid phospholipid-based delivery nanocarriers made from natural and/or synthetic phospholipids and brain cell membranes could overcome these limitations. These hybrid nanocarriers will encapsulate a combination of antioxidant and anti-inflammatory medicines. Through the combination of cell membranes and lipids on their surface, the nanocarriers will cross the BBB. Through the release of the encapsulated cargo, they will reduce oxidative stress and inflammation. The research focuses on improving BBB crossing based on combining natural/synthetic phospholipids and cell membranes and subsequently improving the nanocarriers’ therapeutic efficacy.

Eligibility 

Applicants must have obtained or be about to obtain a First or Upper Second class UK honours degree, or the equivalent qualifications gained outside the UK, in pharmacy, pharmaceutical nanotechnology, materials science, biomedical engineering, chemical engineering, chemistry, physics, or in a relevant subject area. Applicants with nanoparticle synthesis experience or an interest in smart nanomedicines and pharmaceutical nanotechnology are encouraged to apply.

Before you Apply 

Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application.  

How to Apply 

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title - PhD Pharmacy and Pharmaceutical Sciences.

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit https://www.bmh.manchester.ac.uk/study/research/international-phd/

Your application form must be accompanied by a number of supporting documents by the advertised deadlines. Without all the required documents submitted at the time of application, your application will not be processed and we cannot accept responsibility for late or missed deadlines. Incomplete applications will not be considered. If you have any queries regarding making an application please contact our admissions team [Email Address Removed]  

Equality, Diversity and Inclusion  

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/  

Biological Sciences (4) Chemistry (6) Materials Science (24) Medicine (26)

Funding Notes

Applications are invited from self-funded students. This project has a Band 3 fee. Details of our different fee bands can be found on our website https://www.bmh.manchester.ac.uk/study/research/fees/

References

1. Cell Membrane-Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme. https://doi.org/10.1002/adhm.201900612
2. Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS. https://doi.org/10.1016/j.nano.2017.03.022
3. Design, Fabrication, and In Vitro Evaluation of Nanoceria-Loaded Nanostructured Lipid Carriers for the Treatment of Neurological Diseases. https://doi.org/10.1021/acsbiomaterials.8b01033
4. Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy. https://doi.org/10.1039/C8NR05520C
5. Nucleic Acid-Loaded Lipid Nanoparticle Interactions with Model Endosomal Membranes. https://pubs.acs.org/doi/10.1021/acsami.2c06065