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  Hypoxia links the unfolded proteim response with the DNA damage response


   Department of Oncology

This project is no longer listed on FindAPhD.com and may not be available.

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  Prof Ester Hammond, Prof Amato Giaccia  Applications accepted all year round

About the Project

THE PROJECT


PUBLICATIONS
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. Foskolou IP, Jorgensen C, Leszczynska KB, Olcina MM, Tarhonskaya H, Haisma B, D’Angiolella V, Myers WK, Domene C, Flashman E, Hammond EM. Mol Cell. 2017 Apr 20;66(2):206-220.

Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. Katarzyna B. Leszczynska, Iosifina P. Foskolou, Aswin G. Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N. Span, Eric E. O’Neill, Francesca M. Buffa and Ester M. Hammond. J Clin Invest. 2015Jun 1;125(6):2385-2398.

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication. Olcina MM, Foskolou IP, Anbalagan S, Senra JM, Pires IM, Jiang Y, Ryan AJ, Hammond EM. Mol Cell. 2013 Dec 12;52(5):758-66.

Funding Notes

All complete applications received by 12 noon (UK time) on Friday 11 January 2020 will automatically be considered for all relevant competitive University and funding opportunities, including the Clarendon Fund, Medical Research Council funding, and various College funds. Please refer to the Funding and Costs webpage (https://www.ox.ac.uk/admissions/graduate/courses/dphil-oncology) for this course for further details relating to funded scholarships and divisional funding opportunities.

Funded studentships are highly competitive and are awarded to the highest ranked applicant(s) based on the advertised entry requirements for each programme of study.

References

Whilst you must register three referees, the department may start the assessment of your application if two of the three references are submitted by the course deadline and your application is otherwise complete. Please note that you may still be required to ensure your third referee supplies a reference for consideration.

Academic references are strongly encouraged, though you may use up to one professional reference provided that it is relevant to the course.

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