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Identification and characterisation of barriers to antimicrobial resistance gene transfer


Project Description

Antimicrobial resistance (AMR) is a great threat to the future of modern medicine (amr-review.org/Publications). Key multi-drug resistant bacteria and human colonisers that evolve by acquiring antimicrobial resistance genes from other bacteria, exchanging them at high frequency, and competing successfully with the microbiome in the host. We have built laboratory models of this dynamic using clinical isolates of the key AMR pathogen methicillin-resistant Staphylococcus aureus (MRSA) to investigate gene transfer and loss as well as the ability of resistant strains to compete with non-resistant strains.

This project will focus on identifying and characterising new mechanisms that reduce AMR gene transfer. We will investigate the function of genes involved, how they control the evolution of AMR populations, and whether they could be useful new tools for manipulating genomes. This is a cross-disciplinary research project aimed at generating innovative strategies for reducing AMR incidence in the host.

SKILLS WE EXPECT A STUDENT TO DEVELOP/ACQUIRE WHILST PURSUING THIS PROJECT
Identify hypotheses, design experiments to answer the hypotheses, interpret and discuss findings, communicate them in papers and presentations. Microbiology, cloning, phage biology, sequencing, bioinformatics, data analysis. This is a multidisciplinary project with opportunities to collaborate with experts in clinical microbiology, epidemiology, public health, mathematical modelling, and with a focus on translational outcomes to benefit patients.

HOW TO APPLY
Potential applicants are strongly encouraged to contact the supervisors to discuss project details.

The current studentship is part of the MRC London Intercollegiate Doctoral Training Partnership (MRC-LID) between The London School of Hygiene and Tropical Medicine (LSHTM) and St. George’s University of London (SGUL)

Subsequently applications can be made by following the instructions on the MRC-LID site at http://mrc-lid.lshtm.ac.uk/apply/.

Please click on the following link for more information about the MRC-LID programme: http://mrc-lid.lshtm.ac.uk/

For more information on funding please go to: http://mrc-lid.lshtm.ac.uk/faqs/

The deadline for applications is Wednesday 1 January 2020.

Funding Notes

To be eligible for a full studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen, and
(c) have maintained ordinary residence in the UK continuously for the 3 years preceding 1 September 2020.

To be generally eligible for a fees-only studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen.

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