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Identification and Characterization of New Anti-infectives (GCRF)


Project Description

The project will be focused on building predictive models using QSAR, pharmacophores, along with virtual screening for the development of novel anti-infectives with special focus on antifungals. Previously, the majority of anti-fungal compounds target cellular integrity of fungi. Our genome wide studies in A. fumigatus and C. albicans have identified a number of essential enzymes (phosphatases and kinases) for the growth of these pathogens, which constitute attractive targets for antifungal therapy. Our aim is to exploit these targets for the development of novel antifungal drugs. The aim is to provide an integrated pipeline for computational-based identification and selection of leads for drug discovery that is available to the wider community and that can accelerate the generation of new anti-infectives. The hits obtained will be used for library design and to derive novel chemical scaffolds, which will be later validated experimentally (on the target and on fungal cultures). This project will help towards enhancing already available drug discovery tools and will help in identify new anti-infectives with better ADME properties and reduced toxicities.

Entry Requirements
Candidates are expected to hold (or be about to obtain) an Upper Second class Honours degree (or equivalent) in a related area / subject.

If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - choose PhD Infectious Diseases. Full details on how to apply can be found on the GCRF website https://www.manchester.ac.uk/study/postgraduate-research/golden/gcrf/

Funding Notes

The GCRF PhD studentship programme is a 4 year programme with integrated teaching certificate. There are up to 12 studentships available. Applicants can apply to one project which will start in either April or September 2020.

Funding for the programme will include tuition fees, an annual stipend at the minimum Research Councils UK rate (around £15,000 for 2019/20), a research training grant, training allowance and travel allowance.

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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