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Identification and characterization of substrate recognition motifs of Deubiquitinases


About This PhD Project

Project Description

PhD position in the Innovative Training Network UBIMOTIF (ESR8):
Identification and characterization of substrate recognition motifs of Deubiquitinases

Within the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 860517, the Kulathu lab at the MRC Protein Phosphorylation & Ubiquitylation Unit, University of Dundee is offering a 4 year PhD position for an Early Stage Researcher (ESR).

The UBIMOTIF consortium includes 13 research groups and 6 partners from 10 European countries and is a joint training and research program with focus on identification, characterization and exploitation of short linear motifs in the ubiquitin system. Visit http://www.ubimotif.ku.dk for more information.

About the project / job description:
ESR8. Deubiquitinases (DUBs) control the ubiquitylation status of proteins in a cell and have important functions in modulating the outcome of ubiquitylation. For the majority of the DUBs, we have a poor understanding of how they are targeted to their substrates. The objective of this work will be to discover and characterize short linear interaction motifs (SLiMs) that function as substrate recognition motifs in DUBs. To identify substrate motifs, you will employ proteomic peptide phage display (ProP-PD) technology, following which you will apply a combination of biochemical, cell and structural biology approaches to further characterize the specificity determinants of DUB-substrate interactions.

Qualifications:
An undergraduate or master’s degree in a relevant area with strong background in Biology, Biochemistry, Chemistry, Medicine or related fields.

Special requirements:
• Applicants can be of any nationality.
• Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training.
• Applicants must be eligible to enroll in a PhD programme at the host institution.
• Being a PhD student in an ITN includes a considerable amount of travelling including participation in meetings and workshops and stays of periods of a few months outside the host laboratory. Therefore, a requirement is the willingness to travel and stay abroad.

Candidates will be required to meet the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria:

Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the United Kingdom for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account. The earliest possible start date is 1 March 2020 (latest before 31st May 2020).

Early Stage Researcher (ESR) criteria: ESRs must, at the date of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Full-Time Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited, even if a doctorate was never started or envisaged).

You will only be considered for the position if you fulfil (and can prove so) the eligibility criteria. As part of your online application, you are required to complete and upload an Eligibility Declaration Form.

We offer:
• The opportunity to conduct cutting-edge research and access to a network of leading researchers in the field
• Secondment periods at other network partners’ labs
• Participation in research-specific, complementary and soft skills training that involve both the academic and industry sectors, network-wide training activities, schools and conferences

Salary information:
Living Allowance: EUR 54,857.52 per year
Mobility Allowance: EUR 7,200 per year
Family Allowance (if eligible): EUR 6,000 per year

The exact salary will be calculated in GBPs and will contemplate living, mobility and family (if eligible) allowances.

The project will last 36 months. For the 4th year of PhD research, stipend and resources (in line with host institute guidelines) will be covered by the host group.

Deadline for applications is 3 January 2020. To see full job advert and how to apply, please click HERE.


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