About the Project
This project will provide a comprehensive training for a PhD student in a wealth of molecular and cellular approaches, in vivo cardiac functional study on genetically modified mice, electrophysiology and computational simulation methods.
Informal enquiries may be made directly to the primary supervisor.
Liu W, Zi M, Chi H., Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. J Mol Cell Cardiol. 2011;50 (4):702-711.
Kimura TE, Jin JW, Zi M, Prehar S, Liu W, Oceandy D, Abe JI, Neyses L, Weston AH, Cartwright EJ, Wang X. Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response, and Promotes Pressure Overload-Induced Apoptosis in the Heart. Circ Res. 2010;106:961-970.
Liu W, Zi M, Jin JW, Prehar S, Oceandy D, Kimura TE, Lei M, Neyses L, Weston AH, Cartwright EJ, Wang X. Cardiac-Specific Deletion of Mkk4 Reveals Its Role in Pathological Hypertrophic Remodeling, but Not in Physiological Cardiac Growth. Circ Res. 2009;104:904-914.
Zi M, Kimura TE, Liu W, Jin J, Higham J, Kharche S, Hao G, Shi Y, Shen W, Prehar S, Mironov A, Neyses L, Bierhuizen MFA, Boyett MR, Zhang H, Cartwright EJ, Lei M, Wang X. MKK4 deficiency in cardiomyocytes causes connexin 43 remodeling and couples hypertrophic signals to ventricular arrhythmogenesis. J Biol Chem. 2011;286:17821-17830.
Wang, X. (2009) Cre transgenic mouse lines. In Transgenesis, 3rd Edition. Editor: Elizabeth J. Cartwright. Methods Mol Biol. 561, 265-273.
Cartwright, E.J. and Wang, X. (2009) Transgenesis. Molecular Biology and Biotechnology. Editor: JM Walker and R Rapley. 5th Edition, 1-10.
Egom E, Mohamed T, Mamas M, Shi Y, Liu W, Chirico D, Stringer S, Ke Y, Shaheen M, Wang T, Chacko S, Wang X, Solaro S, Fath-Ordoubadi F, Cartwright E, Lei M. Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of amechanism protecting cardiomyocytes against ischemic cell injury. Am J Phyiology. 2011;301(4):H1487-H1495.
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