Identification of new biomarkers of insulin resistance and type 2 diabetes

SUMMARY OF PROJECT

Diabetes represents a global health, social and economic burden. Approximately 425 million people in the world suffer from diabetes and this will rise to 642 million by 2040. Of these, 90% have type 2 diabetes (T2D). The primary risk factor for developing T2D is the inability of tissues to respond appropriately to insulin; known as insulin resistance. This condition can remain undetected for a long time and ultimately will lead to T2D. In the UK it is estimated that 1 million people might have the condition and not know it.
We have discovered that a group of small GTPases in muscle and fat (Rab3 pathway) influence how glucose enter cells and could be a key factor in the development of T2D.

The aim of this PhD is to understand how the Rab3 pathway is regulated, and whether it can be used as an early diagnostic marker of insulin resistance and T2D. The PhD candidate will adopt a multidisciplinary approach: 1. Characterise the Rab3 pathway in skeletal muscle to provide solid basis for understanding its role in the development of T2D 2. Perform an intervention in pre-diabetic humans combining physical activity and diet to investigate how this pathway can be controlled.

We welcome expressions of interest from excellent students keen to develop a wide range of cross-disciplinary skills (biochemistry, cell biology, human physiology). This studentship will support the MRC funded research programme, expanding the reach of this study and providing a unique training opportunity for an ambitious student to be involved in a RCUK-funded project.

https://researchportal.bath.ac.uk/en/persons/francoise-koumanov.

For further information please contact Francoise Koumanov ([Email Address Removed])

APPLICATION CRITERIA

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related subject. Candidates with experience in any molecular and cellular techniques or with an interest in diabetes and metabolic diseases are encouraged to apply.