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Identification of the molecular pathways that guide zebrafish regeneration.

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The study of regenerative biology aims to elucidate the innate ability of organisms to replace tissues or organs after they have been removed or damaged. During vertebrate regeneration, tissue damage causes the immediate release of signals that initiate wound closure and inflammation. Following this, regenerative cells proliferate and migrate to the damaged area. These cells then grow to replace the missing organ or tissue. This process is very efficient in aquatic vertebrates such as salamanders, frogs and fish, and is not very successful in terrestrial vertebrates such as ourselves.

This project uses zebrafish as a model to identify the signals that recruit regenerative cells to the site of injury. Genetic and pharmacolgical inhibition of signalling pathways will be used to identify key regenerative signalling pathways. Time-lapse analysis at the single cell level will be used to analyse the roles of different pathways in attracting and guiding cell migration. The successful candidate will join a supportive and hardworking team of scientists based in the Department of Biomedical Sciences and the Bateson Life Course Biology Centre. The student will use cutting-edge techniques such as CRISPR/Cas9 gene editing, light sheet microscopy and next generation sequencing. The long-term goal of this project is to improve regenerative medicine approaches for patients.

Science Graduate School
As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs to learn more.


You can find more information about Dr Roehl’s research here - https://www.sheffield.ac.uk/bms/research/roehl

Funding Notes

First class or upper second 2(i) in a relevant subject. To formally apply for a PhD, you must complete the University's application form using the following link: View Website

This position does not provide fees and stipend, the applicant must obtain these independently. Applicants must have a First class or upper second 2(i) in a relevant subject. IELTS English score must average 6.5 with 6.0 score for each component. To formally apply for a PhD, you must complete the University's application form using the following link:
View Website




References

(1) “Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells” Maria Romero, Gareth McCathie, Philip Jankun & Henry Roehl. Nature Communications volume 9, Article number: 4010 (2018) (2) “Linking wound response and inflammation to regeneration in the zebrafish larval fin” Henry Roehl. Int. J. Dev. Biol. 62: 473 - 477 (2018)
(3) http://www.roehl.group.shef.ac.uk/Roehl_Research.html

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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