About the Project
Objectives of the PhD
The overall aim of this project is to determine the host-pathogen interface between Tf and the TbTfR at the molecular level and to show that blockage of this interaction is detrimental to the growth of T. brucei. The individual measurable objectives are:
(i) to identify the part of Tf that interacts with the TbTfR by crystal structural analysis of the receptor-ligand complex,
(ii) to design peptides that are able to interfere with the binding of Tf to the TbTfR, and
(iii) to test the peptides for inhibiting the growth of trypanosomes.
For more information on the supervisor, please go here: https://www.uea.ac.uk/medicine/people/profile/d-steverding
This is a PhD programme.
The start date of the project is 1 October 2020.
The mode of study is full-time. The studentship length is 4 years (3 years period of study, 1 year period of registration).
Please note: Applications are processed as soon as they are received and the project may be filled before the closing date, so early application is encouraged.
Acceptable first degree in Biology, Biochemistry, Microbiology, Parasitology, Molecular Biology, Cell Biology, Biological Science, Biomedical Science, Medical Science, Infectious Disease, Medicinal and Biological Chemistry, Chemistry.
The standard minimum entry requirement is 2:1.
ii) Steverding, D., Stierhof, Y.-D., Fuchs, H., Tauber, R. & Overath P. (1995) Transferrin binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei. J. Cell Biol. 131, 1173-1182.
iii) Steverding, D. (1998) Bloodstream forms of Trypanosoma brucei require only small amounts of iron for growth. Parasitol. Res. 84, 59-62.
iv) Steverding, D. (2000) The transferrin receptor of Trypanosoma brucei. Parasitol. Int. 48, 191-198.
v) Steverding, D., Sexton, D.W., Chrysochoidi, N. & Cao, F. (2012) Trypanosoma brucei transferrin receptor can bind C-lobe and N-lobe fragments of transferrin. Mol. Biochem. Parasitol. 185, 99-105
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