Driver gene identification is central to understanding carcinogenesis and patient management. In colorectal cancer (CRC) however the full complement of molecular lesions sufficient to cause CRC, and explain its diversity is unknown. This project will be directed to systematically analyse the non-coding genome for CRC cancer-driving mutations. The size of the non-coding genome places a high burden on robustly establishing statistical significance. Cis-regulatory regulatory elements (CREs) influencing gene expression represent a highly-enriched subset of the non-coding genome in which to identify non-coding drivers. The aim of this proposal is to define the regulatory landscape of CRC by using high-throughput chromosome conformation capture and other state of the art methodologies in combination with computational biology to identify and characterise non-coding drivers for CRC.
Candidates must have a first class or upper second class honours BA or BSc Honours/MSc or equivalent in Natural Sciences or Life Sciences with computing experience
How to apply
Full details about these studentship projects, and the online application form, are available on our website, at: http://www.icr.ac.uk/phds Applications for all projects should be made online. Please ensure that you read and follow the application instructions very carefully.
Closing date: Monday 6th May 2019 Applicants should be available for interview end of May 2019.