About the Project
This project will explore SMA as a way to biopsy cells of the vasculature to obtain proteins and other biomarkers that inform disease diagnosis and/or management. Our targets will be the early markers of clinical atheroma in endothelial and smooth muscle cells, characterising the application in the identification of specific, key markers of a critically-important disease. This will be achieved using cells in culture, then extended to intact human vascular tissue. The techniques involved will include assays of cell viability and functional analyses, with protein characterisation by mass spectrometry and Western blotting. There is the possibility of further collaborative work to carry out analysis of model cells, to precisely establish the limits of detection for this novel cell biopsy technique.
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